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doi: 10.1016/j.fertnstert.2012.11.046 16 SharmaRAgarwalAMohantyGDu PlessisSSGopalanBWillardBet al

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Volume of Distribution Volume of distribution (V) relates the amount of drug in the body to the concentration of drug (C) in blood or plasma: The volume of distribution may be defined with respect to blood, plasma, or water (unbound drug), depending on the concentration used in equation (1) (C = C b , C p , or C u )

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On the other hand, internalization by deltorphin analogues is associated with partial recycling and resensitization of DOR signalling [88], both of which may contribute to a faster recovery of analgesic efficacy upon repeated administration of this type of ligands [86]