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400 Another randomized controlled trial in 4,745 patients with a recent history of heart attack found adding 0.5 mg of colchicine daily to preventive therapy lowered the rate of major cardiovascular events by 23% relative to placebo during a median follow-up of 22.6 months

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Frequency varies depending on your goals and provider recommendations

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For instance, dysbiosis has the potential to lead to T cell population alterations, which in turn may produce a tipping in the balance towards systemic autoimmunity