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53,57,58 A meta-analysis of six randomized controlled trials with a total of 355 participants found myo-inositol was comparable to metformin with regard to its effects on fasting insulin and insulin sensitivity, testosterone, sex hormone binding globulin (SHBG), and body mass index (BMI) (a measure of body weight status) in women with PCOS, while metformin treatment carried a higher risk of adverse effects

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Moreover, GGT-knockout mice (that can be rescued by supplementing drinking water with N-acetylcysteine) will exhibit a plasma cysteine concentration 80% lower than their wild-type counterparts [13]