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Disruption of FR, whether functional or structural, can impair CNS folate availability and lead to developmental abnormalities or neurological dysfunction, with the clinical consequences depending on the timing, severity, and presumably on the individual genetic background

The gestational environment and Parkinson' s disease: evidence for neurodevelopmental origins of a neurodegenerative disorder

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Once contaminated by bacteria, their efficacy may decline at best, and severe infections may occur at worst