melanotic macules definition macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight ⬆️ in single basal melanocytes; NO nests. More info like this in Labial Lentigo (labial melanotic macule)

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A definitive activity remained elusive for many years as conflicting reports described CRP as both pro- and anti-inflammatory activities, and as both pro- and anti-thrombotic [reviewed in ( The confusion concerning CRP's bioactivities only recently began to clarify when it was recognized that the serum soluble non-covalently associated pentameric CRP structure could be induced to dissociate into monomeric subunits

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Potential role of neuroactive tryptophan metabolites in central fatigue: establishment of the fatigue circuit

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J Vasc Med Surg 2(4):14 Hegde S, Akbar H, Zheng Y, Cancelas JA (2018) Towards increasing shelf life and haemostatic potency of stored platelet concentrates