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Untargeted metabolomics analysis Metabolites were extracted from 100 l of CSF using 1.5 ml of 50% methanol (414832, Carlo Erba)/30% acetonitrile (412342, Carlo Erba)/20% water (412112, Carlo Erba) extraction buffer 45

Arterial vascularization of the pineal gland is supplied by both the anterior and posterior circulation, being the main artery supplying the lateral pineal artery, which originates from the posterior circulation (4)

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One such complication is thrombotic microangiopathy (TMA), characterized by thrombocytopenia, hemolytic anemia, and organ damage due to microscopic thrombi formation in capillaries and small arteries, including kidney injury [104,114]

Data Analysis and Interpretation SDS-PAGE : Separate proteins by size to visualize the presence of interacting partners