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The honest position supported by both major 2026 reviews is that the preclinical evidence is mechanistically compelling, no major safety red flags have emerged, and controlled human evidence has been entirely absent
An attractive treatment approach is provided by prodrug therapy
That said, oral supplementation is not without value when sustained over longer periods
Am J Clin Nutr 57 , 4346 (1993)
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122 In the classical theory of GSIS, the glucose is transported into islet cell through GLUT2, and generates pyruvate, entering tricarboxylic acid cycle (TCA) to produce ATP
