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doi: 10.1111/j.1471-4159.2009.06542.x

According to the NICE Clinical Knowledge Summary (CKS) and the British National Formulary (BNF) , the standard treatment for B12 deficiency without neurological symptoms involves: Hydroxocobalamin 1 mg intramuscularly three times weekly for two weeks Followed by maintenance doses of 1 mg every three months For patients with neurological symptoms (such as paraesthesia, numbness, cognitive changes, or gait disturbances), more intensive treatment is required: Hydroxocobalamin 1 mg intramuscularly on alternate days until no further improvement occurs Followed by 1 mg every two months for maintenance Pernicious anaemia , an autoimmune condition where the body cannot produce intrinsic factor, requires lifelong treatment

Whilst B12 (cobalamin) is essential for nerve function, red blood cell production, and DNA synthesis, there is no established direct link between B12 supplementation and joint pain in medical literature

Thus, with the increasing cases of vitamin B12 deficiency, the use of vitamin B12 supplements and intake of vitamin B12 rich foods has increased considerably