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Secondly, although we controlled for current antipsychotic medication intake and metabolite concentrations, possible confounding effects of long-term medication use should be considered

INF/ signaling plays a key role in immune response, and its activation is mediated by Janus kinase (JAK) and signal transducer and activator of transcription (STAT) [45]

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Its thought to work by making more of the milk-producing hormone prolactin

Key Points Intervertebral disc (IVD) degeneration is frequently associated with low back and neck pain The avascularity of the IVD is an obstacle to intrinsic repair by exogenous cells Tissue-specific progenitor cells have been identified in the IVD, and these cells could be targeted to promote intrinsic repair Supplementation of functional cells from exogenous sources has IVD-regenerative effects in basic and preclinical studies A growing number of clinical trials are assessing the effects of cell therapy for IVD disease Despite promising results of cell therapy for IVD disease in preclinical studies, various obstacles remain to define its efficacy and target indications Abstract Intervertebral disc (IVD) degeneration is frequently associated with low back and neck pain, which accounts for disability worldwide