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The occipital artery was ligated permanently and the pterygopalatine artery (PPA) was ligated for the MCAO procedure duration

The Molinspiration interface was used to estimate the molecular properties, pharmacophore features, and bioactivities of the compounds

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Interestingly, IR, inflammation, mitochondrial dysfunction, endoplasmic reticulum (ER) stress, autophagy, and the ubiquitinproteasome system (UPS), independently contribute to the onset and aetiopathogenesis of both T2DM and PD

In the diet, lignans often occur as complex precursors (like secoisolariciresinol diglucoside in flax) that are metabolized by gut microbiota into bioactive forms (54)