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Although BMD is variable in T1DM and T2DM, prolonged hyperglycemia promotes changes in bone metabolism and destroys bone micro-architecture through multiple mechanisms, such as production of AGEs, inflammation, calcium and phosphorus metabolism disorders, and oxidative stress (112)
[DOI] [PMC free article] [PubMed] [Google Scholar] 13.Fernandez H.F
doi: 10.1172/JCI78954
Voehringer DW
A control case study showed pregnant women with HHcy possess a 7.7-fold risk for PE compared with normal controls [101]
The take-home
