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For a person who cannot absorb B12, the injection is a critical, life-sustaining treatment, not a voluntary supplement

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High dose oral supplementation is an effective alternative to parenteral treatment Randomized studies of daily high oral doses of 1,0002,000 g have shown equivalence or superiority to injected B 12

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This is the practical reason a reader who is nervous about small-volume accuracy might prefer the 50 mg protocol the trade-off being that each vial carries fewer total doses, as the supply math shows next

However, unnecessary supplementation offers no added benefit if your B12 levels are already normal