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Studies using mouse models have confirmed that elevated HO-1 not only exacerbates the inflammatory response in macrophage-derived foam cells but also induces ferroptosis, resulting in a significantly increased plaque burden (77)

Zhaoping Li, chief of the Division of Clinical Nutrition and a professor of medicine at UCLA Health

Author contributions GR-N: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing original draft

VR, Bitarello BD, C.B

Purification and characterization of a glutathione reductase from Phaeodactylum tricornutum

Thereby, there were in particular beneficial effects on the liver, including on portal hypertension, and on the intestinal tract[26-32], lung[37-39], thrombosis[21,40], venous[21] and arterial[40], and heart disturbances[41-45], free radicals formation[46-49] and free radical-induced lesions[46-50]