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Bos PH, et al

[DOI] [PMC free article] [PubMed] [Google Scholar] 68.Wellendorph P., Bruner-Osborne H

The downregulation of endothelial nitric oxide synthase (eNOS) activity and reduced nitric oxide (NO) bioavailabilitycaused by pro-inflammatory cytokinesare the core preclinical vascular mechanisms of ED in varicocele patients, as NO is the key mediator of penile vasodilation and erection maintenance (204)

In addition, the authors examined a composite endpoint consisting of three components: 10% reduction in insulin doses, 2% reduction in body weight, and 3 mmol/mol reduction in HbA1c

[DOI] [PMC free article] [PubMed] [Google Scholar] 44.How O.-J., Aasum E., Kunnathu S., Severson D.L., Myhre E.S., Larsen T.S

A ligand for TdfF has not yet been identified, but, as mentioned above, among the possible candidates for iron sources in the intracellular environment (ferritin, iron chelated to organic acids or to glutathione), only ferritin has been shown to contribute to the intracellular survival of N