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Indeed, mouse models demonstrate how easily deformative stretch can lead to abnormal calcium influx (Wolf et al., 2001), altered gene expression (Henderson et al., 2017), proinflammatory stimulation, glial network disintegration (Koumlis et al., 2018) and apoptosis of neurons (Liu et al., 1997

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TP63 gain-of-function mutations cause premature ovarian insufficiency by inducing oocyte apoptosis

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