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Pro-inflammatory cytokines i.e., TNF- and IL-1 may activate the serotoninergic transporter (SERT) via the stimulation of the p38 MAPK pathway, increasing the concentration of other catecholamines in specific brain regions such as the anterior hypothalamus (Zhu et al

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This includes but is not limited to the abdomen, thighs, and arms

[60] Low muscle tone (hypotonia) can be a sign of many underlying conditions, including vitamin deficiencies (B1 and other B vitamins), hypothyroidism, carnitine deficiency, creatine deficiency, and methylation issues, as well as genetic conditions (of which there are hundreds)

doi: 10.1210/me.2005-0479 57 HeemersHVerrijdtGOrganeSClaessensFHeynsWVerhoevenGet al

Finally, 6 (14%) patients in the control group died due to the complications of COVID-19, while all the patients in the intervention group survived ( p = 0.030