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Another recent study reported reduced glutathione only in schizophrenia patients carrying a risk variant of the gene coding for the rate-limiting enzyme in glutathione synthesis [22]

To evaluate the potential of different pathways geared toward improving GSH synthesis, several DNA-mediated integrative expression vectors pGAPh-gsh2gsh1, pGAPg-pro1gshB or pGAPg-proBgshB harbouring different pathway genes were constructed

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The response of cyst(e)ine levels in liver to increasing doses of EtOH is presented in Table 5

Furthermore, genetic factors such as mutations in SNCA gene (encodes alpha-synuclein protein) and Parkin (encodes E3 ubiquitin ligase) also contribute to familial forms of the disease 10
