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Regarding on the inhibition of GLS, the allosteric inhibition mechanism of compound 968 is different from that of BPTES, which is characterized by different binding sites and mainly inhibits GLS in an inactive state

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Pharmacogn Rev 4:118126 [DOI] [PMC free article] [PubMed] [Google Scholar] Longo VD, Mattson MP (2014) Fasting: molecular mechanisms and clinical applications

However, the isolation of antioxidant enzymes in their native form is a very cumbersome and cost-intensive approach, apart from other limitations such as potential immunological problems which can arise during their systemic application as therapeutic agents [69]

169 From the perspective of molecular biophysics, the structural integrity of the ACL is influenced by the molecular composition and organization of its constituent collagen fibers

Knockdown of IREB2 reduces ferroptosis susceptibility (90, 91)