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[cited 2025 Jul 30]

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CNS-directed treatments include intrathecal chemotherapy, CNS-directed systemic chemotherapy, and cranial radiation
The author carefully reviewed her paper and decided which of the many conclusions in the review may have been materially affected by the withdrawal of the Sato papers
Randomized double-blind placebo-controlled (RDP) clinical trials help clarify and confirm some of the mechanisms of action of Pycnogenol at the molecular level

The second weakness is that the safety case is still structurally fragile
