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G.WallaceT

I think that does make a difference in many cases
A proper assortment of H-site residues is crucial to efficient catalysis by forming the cavity binding the hydrophobic substrate

The International Journal of Biochemistry & Cell Biology, 37 (8), 1727-37

Labunskyy VM, Hatfield DL, Gladyshev VN (2014) Selenoproteins: molecular pathways and physiological roles

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