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This enrolled 390 people with type 2 diabetes, all on insulin, and randomised them to metformin 850 mg three times daily or placebo, with a follow-up of just over 4 years (de Jager et al, 2010)

Immune disorders such as Graves disease and lupus

Simultaneously, NAD+ levels increased by 1.2 to 1.6 fold compared to untreated cells

Researchers are exploring whether secondary pathways engaged by AOD9604particularly those independent of 3-adrenergic receptor activationmay modulate lipid profiles, inflammatory markers, or other risk factors in animal models

Further reading Heffernan et al