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Finally, data from mouse studies show that IgG accumulates in white adipose tissue in an FcRn-dependent manner, and that knocking down the receptor by an antisense oligonucleotide targeting the encoding FCGRT gene or deleting expression of FcRn from myeloid cellseffectively turning macrophages into degradative sinks for IgG [381]surprisingly improves metabolic function in mice with diet-induced obesity [382]

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fatigue was the most common side effect in the first week after receiving the vaccine

Tissue-related signaling mechanisms