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Simultaneously, extensive preclinical studies and clinical trials are required to validate the therapeutic applications of EVs or therapeutic vectors in COPD

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41 , 43 Oxidative stress and CKD Oxidative stress plays a pivotal role in the progression of CKD, through glomerular damage and renal ischemia and, indirectly, with inflammation, hypertension, and endothelial dysfunction

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doi: 10.1158/2159-8290.CD-21-0900 88

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