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Alternative Names: Forkhead box protein O4, Proxofim, FOXO4a, AFX, AFX1, MLLT7 FOXO4-DRI Studies and Research Data Investigations in Insulin-Linked Pathways Research indicates that FOXO proteins may operate downstream of insulin and insulin-like growth factor signaling, with potential roles in cellular growth, oxidative stress regulation, and metabolic balance

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Watanabe M, Inoue Y, Sakimura K, Mishina M

This review aims to elucidate the role of ferroptosis in RBI and its therapeutic implications

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Pharmacological targeting of FSP1 strongly synergizes with GPX4 inhibitors to trigger ferroptosis in a number of cancer entities