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Mutant huntingtin impairs BDNF release from astrocytes by disrupting conversion of Rab3a-GTP into Rab3a-GDP

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doi: 10.3390/nu13082612 81

48 Patients should not be treated based on IOP alone, especially if the risk of conversion from OHT to POAG is low, based on age or corneal thickness (see An OHTS Update )

In normal cells, hydrogen peroxide is promptly degraded by either glutathione peroxidase (GSHPX) or catalase, but in red cells of G6PD-deficient subjects, GSHPX activity is impaired because GSH is in short supply (Fig 4), and catalase may also be impaired because the intracellular NADPH concentration is low (Gaetani et al , 1994, 1996)