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The alteration of chloride homeostasis/GABAergic signaling in brain disorders: could oxidative stress play a role

2026 Beyond Basix
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10.1212/wnl.0000000000009474 51 ReedE.LutsenkoS.BandmannO
4 Although some literature states that it may be used as first-line therapy, tramadol lacks FDA approval and is recommended as an alternative to duloxetine, milnacipran, or pregabalin

Paracellular intestinal permeability can be assessed in vivo by using different molecules (e.g., sugars, polyethylene glycols, 51 Cr-EDTA) and ex vivo in Ussing chambers combining electrophysiology and probes of different molecular sizes

621 Investigating alterations in molecular mechanisms related to liver disease and damage repair offers valuable insights into the complexity of these conditions and their treatment ( Fig