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(c,d) Adult male C3H/HeJ mice at 12- to 14-weeks of age underwent chemical sympathectomy by IP injection of 6-OHDA 5- and 3-days prior to ICV implantation for up to 9-days (N = 7 vehicle control, 3 6-OHDA)

In-vivo characterization studies of LNPs encompass a variety of methods to evaluate their performance, distribution, effectiveness, and safety

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Reconstituting a full 30mL vial provides convenience but subjects the entire volume to 28 days of oxidative exposure even under perfect refrigeration, the final doses in week four have lost 1015% potency compared to week one