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As one study puts it, people with the genetic variant that decreases AMPD get muscle cramps, pain, and premature fatigue during exercise.[ref] Symptoms of AMPD1 deficiency: AMPD1 deficiency , also known as myoadenylate deaminase deficiency , has varying effects on exercise performance, heart attack response, and methotrexate (cancer drug) response

Diabetes, 2003

Uptake into brain also occurs primarily via the OCTN2 transporter [1, 44, 45]

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