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Therefore, with the deepening of research, the regulatory pathways of ferroptosis in the antioxidant system are not limited to GSH-dependent antioxidant pathways, but also can play a role in regulating ferroptosis through GSH-independent antioxidant pathways, which means that there may be more regulatory mechanisms related to ferroptosis waiting for us to further explore

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Lichuang Cao, Qian Li, et al

A conserved mitochondrial ATP-binding cassette transporter exports glutathione polysulfide for cytosolic metal cofactor assembly

1H) or 3xTg-AD neurons (Fig

However, insulin sensitivity and glucose tolerance were maintained, likely owing to an increased conversion of saturated fatty acids (known to cause insulin resistance) to monounsaturated fatty acids mediated by stearoyl-CoA desaturase-1 (SCD1) [52]
