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Description
Gastrointestinal and pancreatic neuroendocrine carcinomas (NECs) are poorly differentiated NENs of high malignancy grade and are subdivided into small-cell and large-cell NEC

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Moreover, induction of inflammatory process in the dermis layer and activation of various enzymes including matrix metalloproteinase can cause melasma
doi: 10.1038/nri3225 55 DelpechP-OThuillierRSaintYvesTDanionJLe PapeSvan AmersfoortESet al
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Storage Store the lyophilized vial at 20C, desiccated and protected from light
