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Dental fluorosis prevalence has increased worldwide due to increasing levels of fluoride exposure

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Increased homocysteine can also be caused by a folic acid deficiency, since B-12 helps to regenerate the tetrahydrofolate (THF) active form of folic acid

GSH is preferentially transported in the reduced form as GSSG is virtually impermeable and is entrapped and accumulated in the microsomal lumen creating the oxidizing environment necessary for the formation of disulfide bonds and for the proper folding of proteins [76]