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Inhibition of -KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

Min M, Nadora D, Chakkalakal M, et al

Biochemically, LCD proceeds upon LMP when cells are exposed to various lysosomotropic detergents (e.g., lipid metabolites (phosphatidic acid, sphingosine), ROS), including cathepsins [178,179,180,181] (Fig

That is, even if a medical product receives a new FDA approval or clearance, it may not necessarily be considered new for purposes of new technology add-on payments if it is substantially similar to another medical product that was approved or cleared by FDA and has been on the market for more than 2 to 3 years

Moreover, a crucial advantage of placental tissue cultures concerns the intact microarchitecture, while parallelly ensuring the intercell and paracrine communications [41]

Alcoholic liver disease is the second major worldwide contributor to cirrhosis incidence, accounting for almost one-third of cases (NIDDK 2014a)