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Interestingly, in Phd2 deficient neurons showing a comparatively less pronounced increase of HIF-1 protein abundance (data not shown), PFKFB3 protein levels remained stable, while transcript levels were slightly but significantly increased (Figure S6B) suggesting that up-regulation of PFKFB3 expression, which exceeds the constant proteasomal degradation of PFKFB3 in neurons, may require strong activation of HIF-1

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A reactive oxygen species-responsive hydrogel encapsulated with bone marrow derived stem cells promotes repair and regeneration of spinal cord injury

[00:08:43] Nick: That's really cool too, that you talk about an athletic approach to the whole, both pregnancy as well as the childbirth experience because I feel most people especially in the US, we just look at that as very passive

Conversely, patients taking certain anticonvulsants like Valproic Acid may actually require prescribed carnitine to prevent drug-induced depletion

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