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The key is avoiding receptor desensitization by taking adequate breaks between cycles

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10.1016/s1474-4422(21)00252-0 Lancet Neurol

Thymosin alpha-1: immune modulation for MS While thymosin beta-4 targets remyelination, its thymic cousin thymosin alpha-1 (TA1) addresses the other side of the MS equation: the dysfunctional immune response driving myelin destruction in the first place
Closed pores have no connection to the surroundings and cannot support the diffusion process