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formerly -glutamylcysteine synthetase), which is composed of a heavy or catalytic (GCLC, Mr ~ 73 kDa) and a light or modifier (GCLM, Mr ~ 31 kDa) subunit, which are encoded by different genes in fruit flies, rodents and humans [3741]

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rarely causes clinically visible infections in healthy hosts, but it can be present in latency and persistence inside macrophages [61, 62]

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An association between ROS levels and IFN- response in HIV-1 infection has been reported, whereby HIV-1 reverse transcriptase enzyme-induced increased ROS levels induce stronger IFN- responses 115