glutathione-6-dehydrogenase Understanding and Managing Glucose-6-Phosphate Dehydrogenase Deficiency 6-Phosphogluconate Dehydrogenase Links Cytosolic Carbohydrate

Nature Communications 7:11190

Copper directly associates with the lipoylated proteins of the tricarboxylic acid cycle, leading to the disulfide-bond-dependent aggregation of these lipoylated proteins, destabilization of the iron-sulfur cluster proteins, and consequent proteotoxic stress

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Computer simulation based on the model developed satisfactorily described the reaction kinetics in a wide range of reactant concentrations.