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However, the increased levels of 4HNE in hippocampal homogenates (which aligns with increases we previously reported in cortical homogenates 82 ) but only trend to increase in CA1 4HNE-IR suggests that the major source of 4HNE may not be the neuronal cell body

In response to injury, RGCs upregulate BDNF expression, thereby protecting the remaining cellular population in an autocrine manner, and RGCs survival can also be stimulated by the administration of exogenous BDNF 91,92

IGFBP-3: Insulin-like growth factor-binding protein-3

Schallreuter, K

Particularly, clinical evidence remains inadequate for its traditional uses in skin regeneration, anti-fatigue, and immune enhancement, underscoring the urgent need to bridge the gap between basic research and clinical practice

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