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At the same time, MKLP2 activates ARK5 or ARK5 inhibits PP1 activity, thereby decreasing GSK3 activity, increasing nuclear translocation of Nrf2 and inhibiting ferroptosis [120]

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35 However, what is often overlooked is the fact that the mice were fed a diet deficient in vitamin E and high in soybean oil, which substantially increased the hepatic contents of PUFAs (20:4

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