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During IR, ferritinophagy induces intracellular iron overload, leading to ferroptosis

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6.4 Solid lipid nanoparticles SLNs are submicron-sized particles of solid lipids that could encapsulate lipophilic and hydrophilic drugs (Figure 10)

doi: 10.1152/physrev.00050.2017

So instead of temporary fixes we took a different approach

c-MET inhibition using savolitinib significantly suppressed sphere formation by the patient-derived CRC cells with low ABHD5 and high MET expression, indicating that inhibiting c-MET is an effective strategy for eradicating the CRC stem cell compartment, characterized as low ABHD5 and high c-MET expression (Gu et al., 2021)