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18 Overall, however, the combination of medications for AUD, due to the synergistic effect of medications with different mechanisms of action and cautions/ contraindications/drug interactions, is hampered by a lack of evidence in the literature

These copper-dependent enzymes play a key role in the final stages of cellular respiration [75]

They can bind to proteins and lipids, stabilize the structure of nerve cells and synapses (Martin, 2002), and are used as a source of cellular energy (Varki, 2017), which are essential nutrients for the brain (Nelson et al., 2012)
doi: 10.3390/cells9091983 32 ChenY.ZhangX.YangT.BiR.HuangZ.DingH.et al

Fan Z, Yao J, Li Y, Hu X, Shao H, Tian X
doi: 10.1093/ecco-jcc/jjv094
