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La deficiencia de vitamina B12 a largo plazo de ms de 3 meses puede resultar en lesiones degenerativas irreversibles de la mdula espinal (SNC)

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Nat Neurosci 13:12161224 Jocoy EL, Andre VM, Cummings DM, Rao SP, Wu N, Ramsey AJ, Caron MG, Cepeda C, Levine MS (2011) Dissecting the contribution of individual receptor subunits to the enhancement of N-methyl-d-aspartate currents by dopamine D1 receptor activation in striatum

In one patient, normal DHPR activity was documented

presented at: ISPOR 20th Annual International Meeting, 2015 May 16 - 20, Philadelphia PA
