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[DOI] [PMC free article] [PubMed] [Google Scholar] Nguyen AV, Soulika AM (2019) The dynamics of the skins immune system

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The synaptic function of several of the metabotropic glutamate receptors is altered in autism spectrum disorder, and glutamatergic neurons are important here

They bind to specific receptors and lower the production of pro-inflammatory messengers called cytokines, while often promoting repair at the same time

The overstimulation of neurons activates microglia, the resident immune cells of the brain, which release proinflammatory cytokines, such as TNF- and IL-1, as well as ROS (Figure 1)