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Serum levels of APPs (Hp, SAA, Cp), ALT, AST, GGT, LDH, BUN, creatinine, triglyceride, cortisol and CRP were significantly (P0.05) increased in diarrheal buffalo calves, while serum levels of glucose, total protein, albumin, globulin, calcium, phosphorus, sodium, copper, zinc and iron were decreased