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The function of Parkin in mitophagy was not fully understood until a key study, carried out in 2008 [172], showed that Parkin facilitates the autophagic clearance of damaged mitochondria by being specifically attracted to mitochondria with diminished m after treatment with a mitochondrial uncoupler [172]

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Despite its importance, B12 deficiency is remarkably common particularly among vegetarians, older adults, individuals with digestive conditions, and anyone whose body has difficulty absorbing this vitamin from food or oral supplements

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