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On the other hand, the metabolic reprogramming of macrophages under microenvironment stimuli, involving oxidative stress, mitochondrial dysfunction, and metabolic pathways such as glycolysis, lipogenesis, amino acid metabolism, and microbial metabolism, is closely related to their polarization direction and functional expression, contributing to the pathogenesis of COPD

Lipoprotein transendothelial transport plays a crucial role in the development of atherosclerosis

doi: 10.3389/fonc.2019.01124

37 HeikkilaMPSarisPE

This effect involves the COPS8-mediated interorgan communication pathway, regulating inflammatory responses in microbiota-rich intestinal environments

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