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The remaining amino acids that make up the core of the G-site are more variable across GSTs but are thought to aid in the positioning of GSH in the G-Site [84]

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[DOI] [PubMed] [Google Scholar] 178.Biteau B, Labarre J, Toledano MB

The MG levels indirectly indicate the importance of each of these enzymes in MG detoxification under stress conditions

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Hereditary hemochromatosis, characterized by a recessive mutation in the hemochromatosis (Hfe) gene, has been shown to elevate malondialdehyde (MDA) levels in colonic tissues of Hfe gene knockout mice, suggesting that iron overload promotes oxidative damage to intestinal cells