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This polymorphism increases thermolability [9] and reduces the enzymes affinity for FAD, leading to a 35% decrease in enzyme efficiency per mutated allele [1]

[DOI] [PMC free article] [PubMed] [Google Scholar] 40.Chia SB, Elko EA, Aboushousha R, Manuel AM, Van De Wetering C, Druso JE, Van Der Velden J, Seward DJ, Anathy V, Irvin CG, et al

For B12 deficiency, a typical injection dose is 1,000 mcg once a week for 4 to 8 weeks and then 1,000 mcg once a month

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Nutr Res Pract 3:265271

1 Serum Base