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Two of the most promising drug candidates, indole derivative inhibitors such as efipladib (developed by Wyeth Research) and 2-oxoamide inhibitors (developed by Yaksh et al ., 2006), have shown success in reducing inflammatory effects in animal models

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A 2022 systematic review compared the use of amitriptyline with current FDA-approved medications (duloxetine, milnacipran, and pregabalin)

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3,15 The reason for the discrepancy between estimated and directly measured LDL-C stems from the fact that the equation assumes a fixed ratio (5:1) of TG to VLDL-C