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The Nakayama Alzheimer's disease study demonstrated that cognitive function in older adults, including controls, patients with mild cognitive impairment, and those with AD, was linked to alterations in plasma metabolites such as reduced levels of lysine, ornithine, and uracil (Ozaki et al., 2022)

Coester B, Koester-Hegmann C, Lutz TA, Le Foll C

doi: 10.1038/nri2691 45 XuLYangTWenMWenDJinCAnMet al

Then, BFI was derived by fitting \(g_2(\tau )\) curves with the model described previously

10.1073/pnas.0509588102 89 LaunA