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In postmarketing studies, addiction, abuse, misuse, and fatal and non-fatal opioid overdose were observed in patients with long-term opioid use [ADVERSE REACTIONS]

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Oxidative stress occurs from normal cellular processes but increasingly from pollution, toxins, stress, and other exposures of modern life

Curr HIV/AIDS Rep 18(5):436442 Yuan SB, Shi Y, Chen J, Zhou X, Li G, Gelman BB, Lisinicchia JG, Carlton SM, Ferguson MR, Tan A, Sarna SK, Tang SJ (2014) Gp120 in the pathogenesis of human immunodeficiency virus-associated pain

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Anticancer activity in vivo As a next step, the antitumor activity of our platinum(IV) prodrugs BSO-OxMal and BSO-OxOAc was evaluated and compared at equimolar conditions to free oxaliplatin at the maximum tolerated dose (MTD) of 9 mg/kg